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KMID : 0383820100690030201
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Tuberculosis and Respiratory Diseases
2010 Volume.69 No. 3 p.201 ~ p.206
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Two Cases of Nontuberculous Mycobacterial Lung Disease in Heart Transplant Recipients
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Jo Jung-Min
Shin Mi-Seon
Kim Joo-Hui
Kim Min-Jung
Park Hyun-Jung
Na Hee-Kyung
Jo Kyung-Uk
Kim Jae-Joong
Shim Tae-Sun
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Abstract
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Nontuberculous mycobacterial (NTM) diseases are increasing worldwide. However NTM lung disease in organ transplant recipients has been rarely reported. Here, we report 2 cases of NTM lung disease in heart transplant recipients. A 37-year-old man, who had undergone a heart transplant one year previous, was admitted to hospital due to a cough. Chest CT scan showed multiple centrilobular nodules in both lower lungs. In his sputum, M. abscessus was repeatedly identified by rpoB gene analysis. The patient improved after treatment with clarithromycin, imipenem, and amikacin. An additional patient, a 53-year-old woman who had undergone a heart transplant 4 years prior and who suffered from bronchiectasis, was admitted because of purulent sputum. The patient’s chest CT scan revealed aggravated bronchiectasis; M. intracellulare was isolated repeatedly in her sputum. Treatment was successfully completed with clarithromycin, ethambutol, and ciprofloxacin. NTM lung disease should be considered as a potential opportunistic infection in organ transplant recipients.
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KEYWORD
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Mycobacteria, Atypical, Heart Transplantation, Lung Diseases
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